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Titlebook: Metabolism in Cancer; Thorsten Cramer,Clemens‘A. Schmitt Book 2016 Springer International Publishing Switzerland 2016 Cancer-specific meta

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书目名称Metabolism in Cancer
编辑Thorsten Cramer,Clemens‘A. Schmitt
视频video
概述Covers a variety of important aspects of cancer-associated metabolism.Presents and discusses the latest discoveries in the field.Written by internationally respected experts.Includes supplementary mat
丛书名称Recent Results in Cancer Research
图书封面Titlebook: Metabolism in Cancer;  Thorsten Cramer,Clemens‘A. Schmitt Book 2016 Springer International Publishing Switzerland 2016 Cancer-specific meta
描述This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications.Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
出版日期Book 2016
关键词Cancer-specific metabolism; Glycolysis; Mitochondria; Oncogenes; Lactate
版次1
doihttps://doi.org/10.1007/978-3-319-42118-6
isbn_softcover978-3-319-82501-4
isbn_ebook978-3-319-42118-6Series ISSN 0080-0015 Series E-ISSN 2197-6767
issn_series 0080-0015
copyrightSpringer International Publishing Switzerland 2016
The information of publication is updating

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The Role of pH Regulation in Cancer Progression,. Cellular function depends on pH homoeostasis, and thus, tumours become dependent on pH regulatory mechanisms. Many of the proteins involved in pH regulation are highly expressed in tumours, and their expression is often of prognostic significance. The more acidic tumour microenvironment also has i
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Metabolic Features of Cancer Treatment Resistance,fferent disease types, and independent from the therapeutic approach undertaken. In recent years, subpopulations of slow-cycling cells endowed with enhanced tumorigenic potential and multidrug resistance have been isolated in different tumors, and mounting experimental evidence suggests these resist
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Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome,eds of biological samples in a high-throughput manner. Over the past few years, both technologies were utilized to analyze large cohorts of fresh frozen breast cancer tissues. Metabolite biomarkers were shown to separate breast cancer tissues from normal breast tissues with high sensitivity and spec
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Mathematical Modeling of Cellular Metabolism,nergy-rich bonds of organic phosphates) and a wide array of organic molecules serving as catalysts (enzymes), information carriers (nucleic acids), and building blocks for cellular structures such as membranes or ribosomes. Metabolic modeling aims at the construction of mathematical representations
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