Titlebook: Metabolic Pathway Design; A Practical Guide Pablo Carbonell Textbook 2019 Springer Nature Switzerland AG 2019 metabolic engineering.synthet

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Getting on the Path to Engineering Biologyhas come a long way from its early starts as garage biology into defining a novel paradigm in biotechnology. Nowadays, synthetic biology is a burgeoning technology bringing together biologists, biochemists, computer scientists, physicists, industrial engineers, economists and sociologists. Metabolic

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Pathway Modelingior of an engineered pathway using kinetic models can provide valuable insights in order to identify what are the rate-limiting steps and how are they interrelated with the flux exchanges of endogenous precursors in the cell. Moreover, understanding the dynamics of the metabolic pathway is a first s

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Pathway Selectionsis. The number of alternative pathways can be very high. Pathway enumeration techniques allow determining the alternatives in a systematic way. In this chapter, we will introduce elementary flux mode analysis as one of the most successful approaches for pathway enumeration. Those enumerated pathway

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Pathway Designthway design in order to move into the engineering aspects of metabolic pathway design. Our focus from now on will not be on reproducing through simulation some biological behavior or trying to understand its mechanism but in determining the possible biological interventions and modifications to be