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Titlebook: Metabolic Pathway Design; A Practical Guide Pablo Carbonell Textbook 2019 Springer Nature Switzerland AG 2019 metabolic engineering.synthet

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发表于 2025-3-21 18:27:57 | 显示全部楼层 |阅读模式
书目名称Metabolic Pathway Design
副标题A Practical Guide
编辑Pablo Carbonell
视频video
概述Offers real-world, hands-on examples of scientific coding.Written for biologists and engineers alike.Focuses on the Design-Build-Test-Learn cycle applied to metabolic engineering.Includes lab protocol
丛书名称Learning Materials in Biosciences
图书封面Titlebook: Metabolic Pathway Design; A Practical Guide Pablo Carbonell Textbook 2019 Springer Nature Switzerland AG 2019 metabolic engineering.synthet
描述.This textbook presents solid tools for in silico engineering biology, offering students a step-by-step guide to mastering the smart design of metabolic pathways. The first part explains the Design-Build-Test-Learn-cycle engineering approach to biology, discussing the basic tools to model biological and chemistry-based systems. Using these basic tools, the second part focuses on various computational protocols for metabolic pathway design, from enzyme selection to pathway discovery and enumeration. In the context of industrial biotechnology, the final part helps readers understand the challenges of scaling up and optimisation. By working with the free programming language Scientific Python, this book provides easily accessible tools for studying and learning the principles of modern in silico metabolic pathway design. Intended for advanced undergraduates and master’s students in biotechnology, biomedical engineering, bioinformatics and systems biology students, the introductory sections make it also useful for beginners wanting to learn the basics of scientific coding and find real-world, hands-on examples..
出版日期Textbook 2019
关键词metabolic engineering; synthetic biology; systems biology; pathway design; industrial biotechnology; scal
版次1
doihttps://doi.org/10.1007/978-3-030-29865-4
isbn_softcover978-3-030-29864-7
isbn_ebook978-3-030-29865-4Series ISSN 2509-6125 Series E-ISSN 2509-6133
issn_series 2509-6125
copyrightSpringer Nature Switzerland AG 2019
The information of publication is updating

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发表于 2025-3-21 22:49:31 | 显示全部楼层
Enzyme Discovery and Selection, you will learn some basic techniques based on homology modeling both of the sequence and the chemical reaction allowing to guide us when selecting enzyme sequence candidates. Based on such approaches, at the end of this chapter we will discuss how to expand natural capabilities of enzymes through promiscuity.
发表于 2025-3-22 02:56:59 | 显示全部楼层
Pathway Discoverythe existence and feasibility of biosynthetic pathways connecting the target to the chassis. Generalized reaction rules in the bioretrosynthesis analysis can be applied in order to predict de novo or hypothetical routes based on enzyme promiscuity.
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Pathway Modeling(ribosome binding site) control by means of selection of genetic parts. In this chapter, you will learn some basic models for the main genetic parts that are involved in an engineered metabolic pathway and the tools for simulating their dynamic response.
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Modeling Chemical Diversityreactions. Even more interestingly, we will see how the grammar can be potentially used to enumerate any possible reaction and any possible compound that can be produced in nature. At the end of this chapter, we should have gained a good understanding of the biochemical space that exists in nature.
发表于 2025-3-22 19:13:46 | 显示全部楼层
Pathway Designe this book is about metabolic pathway design, metabolism will continue as our central topic. However, we will also consider solutions that go beyond metabolism and will take advantage of the advanced capabilities that synthetic biology provides to metabolic engineering.
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ossar erklärt die wichtigsten Statistik-Begriffe, Verteilungstabellen helfen beim Durchführen der Tests. NEU ist das ausführliche Stichwortverzeichnis sowie noch ausführlichere Anleitungen (rund 200 Seiten) zur978-3-642-05270-5Series ISSN 0937-7433 Series E-ISSN 2512-5214
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