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Titlebook: Membrane Protein Structure and Dynamics; Methods and Protocol Nagarajan Vaidehi,Judith Klein-Seetharaman Book 2012 Springer Science+Busines

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书目名称Membrane Protein Structure and Dynamics
副标题Methods and Protocol
编辑Nagarajan Vaidehi,Judith Klein-Seetharaman
视频video
概述Lists the necessary materials and provides the needed background information for all experiments.Provides step-by-step detail essential fro reproducible results.Contains key notes and implementation a
丛书名称Methods in Molecular Biology
图书封面Titlebook: Membrane Protein Structure and Dynamics; Methods and Protocol Nagarajan Vaidehi,Judith Klein-Seetharaman Book 2012 Springer Science+Busines
描述.Membrane proteins play key roles in numerous cellular processes, in particular mediating cell-to-cell communication and signaling events that lead to a multitude of biological effects. Membrane proteins have also been implicated in many critical diseases such as atherosclerosis, hypertension, diabetes and cancer. In .Membrane Protein Structure Predictions Methods: Methods and Protocols,. expert researcher in the field detail the advances in both experimental and computational approaches of the structure, dynamics and interactions of membrane proteins dividing the volume into two sections. The first section details the procedures used for measurements of structure and dynamics of membrane proteins. While the second section contains a survey of the computational methods that have played a critical role in membrane protein structure prediction as well as in providing atomic level insight into the mechanism of the dynamics of membrane receptors. Written in the highly successful .Methods in Molecular Biology.™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory..Thorough and intuiti
出版日期Book 2012
关键词X-ray crystallography; crystallography; igand protein; infrared spectroscopy; mass spectrometry; membrane
版次1
doihttps://doi.org/10.1007/978-1-62703-023-6
isbn_softcover978-1-4939-6233-4
isbn_ebook978-1-62703-023-6Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC 2012
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LITiCon: A Discrete Conformational Sampling Computational Method for Mapping Various Functionally Senal selective conformational states starting from the inactive state of the receptor..LITiCon has been applied to map the conformational ensemble of β2-adrenergic receptor, a class A GPCR. We have shown that β2-adrenergic receptor samples a larger conformational space in the ligand-free state and th
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Homology Model-Assisted Elucidation of Binding Sites in GPCRsach, (b) predicting potential binding pockets, (c) docking known binders, (d) analyzing predicted interactions and comparing with positions that have been shown to bind ligands in other receptors, (e) validating the structural model by mutagenesis.
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Book 2012nto the mechanism of the dynamics of membrane receptors. Written in the highly successful .Methods in Molecular Biology.™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory..Thorough and intuiti
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