Titlebook: Membrane Protein Structure and Dynamics; Methods and Protocol Nagarajan Vaidehi,Judith Klein-Seetharaman Book 2012 Springer Science+Busines

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UV–Visible and Infrared Methods for Investigating Lipid–Rhodopsin Membrane Interactionsopsin in a membrane bilayer environment. The combination of FTIR and UV–visible difference spectroscopy is used to monitor the structural and functional changes during rhodopsin activation. Investigations of how membrane lipids stabilize various rhodopsin photoproducts are analogous to mutating the

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Proteomic Characterization of Integral Membrane Proteins Using Thermostatted Liquid Chromatography Ccompatible with proteomic analyses. This chapter describes the coupling of multiple crucial steps that lead to the optimized shotgun proteomic analysis of integral membrane proteins while maintaining empirical topology information. Namely, a membrane shaving method is utilized to separate protease a

Arresting

LITiCon: A Discrete Conformational Sampling Computational Method for Mapping Various Functionally Secal and pathological functions. GPCRs get activated upon ligand binding and trigger the signal transduction process. GPCRs exist in multiple inactive and active conformations, and there is a finite population of the active and inactive states even in the ligand-free condition. An understanding of th

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Homology Model-Assisted Elucidation of Binding Sites in GPCRsmental elucidation of GPCR structures remains a formidable challenge. Homology modeling of 3D structures of GPCRs provides a practical tool for elucidating the structural determinants governing the interactions of these important receptors with their ligands. The working model of the binding site ca

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Comparative Modeling of Lipid Receptorsized three-dimensional structures. The method is particularly important for modeling membrane-bound receptors in the G Protein-Coupled Receptor (GPCR) family, such as many of the lipid receptors (such as the cannabinoid, prostanoid, lysophosphatidic acid, sphingosine 1-phosphate, and eicosanoid rece

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