Titlebook: Melt Extrusion; Materials, Technolog Michael A. Repka,Nigel Langley,James DiNunzio Book 2013 American Association of Pharmaceutical Scienti

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Manufacture of Pharmaceutically Relevant Materials by Mechanochemistry Using Twin Screw Extrusionutical materials, mechanochemistry has been described in the literature for the preparation of cocrystals, salts, and amorphous complexes. In almost all these examples, laboratory-scale mills have been used to demonstrate the production of the aforementioned materials. While laboratory-scale mills d

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Excipient or API Melt Processing via Injection Moldingtion molding process to produce shaped thermoplastic polymer products reproducibly, inexpensively and rapidly, with only minimum industrial waste stream. Industrial waste generated aside, it then addresses the question of whether the existing injection molding processes and equipment are appropriate

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Solid Lipid Extrusionextrusion can be performed at room temperature or up to approximately 70 °C. Plasticity is achieved by a thermomechanical treatment of the lipids without melting the bulk part of the lipid. The extrusion process is simple and robust and can be integrated with several downstream processes into a cont

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Formulation, Bioavailability, and Manufacturing Process Enhancement: Novel Applications of Melt Extry more recent introduction into pharmaceutical processing, challenges in the development of extrusion based formulations/processes as well as the strategies to resolve them may not be as widely understood as the benefits. This chapter illustrates strategies to resolve challenges in the development o

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Hot Melt Extrusion as a Continuous Pharmaceutical Manufacturing Processs on continuous hot melt extrusion (HME) processing as well as on the continuous downstream options that are available. Furthermore, process analytical technology (PAT) tools and the integration of such tools in process control environment are presented. In general, real-time pharmaceutical process

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