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Titlebook: Melanoma Development; Molecular Biology, G Anja Bosserhoff Book 20111st edition Springer-Verlag/Wien 2011 Melanoma.Senescence.Stem Cells.Tu

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书目名称Melanoma Development
副标题Molecular Biology, G
编辑Anja Bosserhoff
视频video
概述Clearly structured book presenting all relevant aspects of malignant melanoma from basic research to therapeutic concepts.Excellent authors contribute to this book.Nowhere else a book focussing on bot
图书封面Titlebook: Melanoma Development; Molecular Biology, G Anja Bosserhoff Book 20111st edition Springer-Verlag/Wien 2011 Melanoma.Senescence.Stem Cells.Tu
描述The book provides comprehensive insights into molecular changes in malignant melanoma. The general mechanisms of melanoma growth and development are described, as well as new research findings. Our current knowledge on the molecules involved in cell transformation and tumor progression will soon lead to sophisticated, targeted therapies. Recent studies with targeted b-RAF inhibitors have given us grounds to hope that these therapies will be successful. Melanoma Development- Molecular Biology, Genetics and Clinical Application aims to contribute to this knowledge. Summarizing the newest data and presenting upcoming research areas in the field, the book will be of great interest to basic researchers and physicians working in the important fields of melanoma, cancer research, therapy and dermatology.
出版日期Book 20111st edition
关键词Melanoma; Senescence; Stem Cells; Tumor Microenvironment; skin carcinoma
版次1
doihttps://doi.org/10.1007/978-3-7091-0371-5
isbn_ebook978-3-7091-0371-5
copyrightSpringer-Verlag/Wien 2011
The information of publication is updating

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Epidermal Melanocytes: Regulation of Their Survival, Proliferation, and Function in Human Skin,iscuss the significance of paracrine and autocrine factors and their signaling pathways in modulating the survival, proliferation, and function of melanocytes, constitutively, and in response to solar ultraviolet radiation (UV), a major environmental stressor and etiological factor for skin cancers,
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Melanoma Genetics and Genomics,r the formation of melanoma. The first pathway involves relatively young individuals with large numbers of nevi and who develop melanomas on locations (e.g., trunk) that are intermittently UV exposed. This pathway is further corroborated by the fact that . mutations, which frequently occur in nevi,
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,Cell–Cell and Cell–Matrix Contacts in Melanoma and the Tumor Microenvironment,their ligands; (4) loss of anchorage to the basement membrane due to altered expression of cell–matrix adhesion molecules; (5) increased expression of metalloproteinases..Melanoma depends on, interacts with and reacts to its stroma, including extracellular matrix, growth factors, cytokines, fibrobla
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