Titlebook: Melanoma; David E. Fisher,Boris C. Bastian Reference work 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 melanoma

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Key Signaling Pathways in Normal and Neoplastic Melanocyteslated during the transformation of melanocytes, often due to somatic mutation of genes within the pathway. One major signaling pathway that highlights this paradigm is the mitogen-activated protein (MAP) kinase pathway. Growth factor signaling via the MAP kinase pathway is required for melanocyte pr

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nonchalance

Biology of Melanoma Metastasisrare in melanoma, but regional and distant metastasis, particularly in the brain, bone, lung and liver, may arise even many years after primary tumor resection, probably due to reactivation of dormant melanoma cells. Dormancy of dispersed melanoma cells is regulated by tumor cell intrinsic as well a

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Melanomics: Comprehensive Molecular Analysis of Normal and Neoplastic Melanocytesf melanocytes and melanomas, which has resulted in the development of therapies that have impacted patient outcomes. This chapter will review studies that have characterized the melanoma genome, transcriptome, as well as the epigenome of non-acral, cutaneous, and uveal melanoma. Specifically, first-

constellation

Inherited Contributions to Melanoma Riskics plays a significant role in both the context of high-risk melanoma families as well as the general population. While two high-risk melanoma susceptibility genes, . and ., have been known for decades, technological advances in recent years have enabled the recent identification of numerous genes

STENT

Epidemiology of Melanocytic Neoplasiaic has led to epidemiologic and clinical studies to elucidate risk factors for cutaneous melanoma. The risk of melanoma varies by race and ethnicity. Lower socioeconomic status is associated with more advanced melanoma at the time of diagnosis. Identified risk factors for cutaneous melanoma include