Titlebook: Medullary Thyroid Cancer; Tracy S. Wang,Douglas B. Evans Book 2016 Springer International Publishing Switzerland 2016 Prophylactic Thyroid

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Gilbert J. Cote,Rozita Bagheri-Yarmand,Marie-Claude Hofmann,Robert F. Gagel

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History and Epidemiology,e same gene underlie a significant proportion of sporadic tumors. Importantly, direct genetic testing allows for presymptomatic identification of patients at high risk for developing thyroid cancer during their lifetime. Early thyroidectomy may be performed in patients who are found to have inherite

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Molecular Mechanisms of Disease: The RET Proto-oncogene,els relative to most other cell types; therefore, aberrant activation of the receptor is thought to preferentially sensitize these cells to transformation. A role of . in medullary thyroid carcinoma has also served to highlight the importance of the MAPK and PI3K signaling pathways in its initiation

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Surgical Management of Parathyroid and Adrenal Glands in Inherited Medullary Thyroid Carcinoma,fe surgical option discussed in depth in this chapter. Primary hyperparathyroidism is reported to develop in 20–30 % of patients with MEN2 and is generally mild. It may be diagnosed synchronously with medullary thyroid cancer or more likely, after thyroidectomy, but it is rarely the presenting diagn

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Importance of Thyroid Hormone Replacement Therapy in Patients with Medullary Thyroid Cancer,affect patients across their life span. These include remembering to take LT4 during childhood and adolescence, increased LT4 requirement during pregnancy in young adulthood, and avoidance of iatrogenic thyroid disease in all treated patients, but particularly avoidance of iatrogenic hyperthyroidism