Titlebook: Mechanisms of Vascular Defects in Diabetes Mellitus; C.C. Kartha,Surya Ramachandran,Radhakrishna M. Pil Book 2017 Springer International P

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Endothelial Progenitor Cell Dysfunction in the Pathogenesis of Vascular Complications of Diabetesons affecting both large and small blood vessels. A major challenge is the discovery of new mediators and biomarkers for diabetes-related vascular complications. In this regard, accumulating evidence indicate that endothelial progenitor cells (EPCs), derived from the bone marrow and peripheral blood

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Pathogenetic Mechanisms in Diabetic Retinopathy: From Molecules to Cells to Tissuesical features categorizes diabetic retinopathy into different severity stages (mild to very severe), where vision loss is eminent in the advanced stages of diabetic retinopathy. Further, each stage of diabetic retinopathy is associated with unique pathological features at the cellular level such as

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Adipokines and Vascular Disease in Diabetesng other homeostatic processes, inflammation, fat distribution, satiety and vascular function. It is important to highlight that, during obesity, the pattern of secreted molecules can change towards an overproduction of proinflammatory, diabetogenic and pro atherogenic ones. In diabetic patients, va

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G-Proteins in Vascular Complications of Diabetesnd chronic hyperglycemia appears to be an important contributing factor in this process. However, the precise mechanism(s) responsible for hyperglycemia-induced vascular dysfunction remains poorly characterized. Guanine nucleotide regulatory proteins (G-proteins) play a key role in the regulation of

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Histone Deacetylases in Vascular Pathophysiology: Regulation by Vasoactive Peptides and Growth Factocation, oxidative stress, inflammation and alterations in the levels/action of vasoactive peptides and growth factors have been suggested as potential mediators of vascular dysfunction. Phenotypic modulation of vascular smooth muscle cells (VSMC) from a quiescent, contractile to a synthetic prolifer

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Role of Non-coding RNAs in Vascular Complications of Diabetes Mellitusthe vascular system by regulating target gene expression. Significant dysregulation of ncRNAs is associated with hyperglycemia, angiogenesis and vascular repair and contribute to vascular disease in patients with diabetes. The functional roles of only a very few ncRNAs such as miRNAs are well studie

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Book 2017ing of the pathogenesis and pathophysiology of vascular diseases in diabetes mellitus. This attempt is significant given the increasing interest in this area as the prevalence of vascular diseases continues to escalate globally. Patients with diabetes are at a higher risk of structural and functiona

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Adipokines and Vascular Disease in Diabetesscular dysfunction is an important risk factor for cardiovascular diseases. Considering the importance of adipokines in vascular function, here we present a brief review of the relevant aspects involved in the influence of adipokines in the establishment of vascular diseases in diabetes.