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Titlebook: Mechanisms of Stimulus—Response Coupling in Platelets; J. Westwick,M. F. Scully,V. V. Kakkar Book 1985 The Editor(s) (if applicable) and T

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Receptor-Effector Coupling in Platelets: Roles of Guanine Nucleotidesreceptors. Two immediate effects of the activation of stimulatory platelet receptors have been well documented» namely inhibition of adenylate cyclase. and the cleavage of membrane phosphoinositides to diacylglycerol and inositol phosphates by phospholipase C.. Initial attempts. at correlating the i
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r a rigorous study of boundary integral equation methods for Helmholtz and Maxwell equations and the proofs of the theorems we refer the reader to [29]. In Section 5.4 we will then sketch an approach for ..—boundary data. These non-smooth boundary data are important for studying questions of existen
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Fibrinogen and Platelet Functiond. It is well established, however that a specific stimulus and an exogenous cofactor with adhesive properties are necessary for aggregation to occur. Early studies on patients with congenital afibrinogenemia have provided evidences that fibrinogen fulfills the role of essential cofactor in this rea
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Agonist-Induced Inositol Phospholipid Metabolism and Ca++ Flux in Human Platelet Activation of second messenger molecules including cAMP, cytosolic free Ca. (Caf) and 1,2-diacylglycerol (DAG).. These second messengers activate specific protein kinases, respectively cAMP-dependent protein kinase. Ca.-calmodulin-dependent protein kinase and protein kinase C. that mediate the phosphorylation
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Platelet Membranes, Eicosanoid Biosynthesis and Putative Endogenous Calcium Ionophoresor orientations. In relation to the platelet, problems arise due to the small size of this cell and its resistance to breakage by mechanical stress forces and further by the requirement to prevent aggregation and degranulation during the preparative procedures.
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