Titlebook: Mechanisms of Lymphocyte Activation and Immune Regulation VIII; Autoimmunity 2000 an Sudhir Gupta Book 2001 The Editor(s) (if applicable) a

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Control of Autoreactive T Cell Activation by Immunoregulatory T Cells (Art)origin and the modalities of such activation of autoreactive B or T cells in spontaneously occurring autoimmune diseases. On the other hand, it appears that the progression to clinical manifestations in these diseases is often very slow and preceded by a long phase of preclinical autoimmunity which

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Immune Tolerance and the Nervous Systemcell or B cell and its clonal progeny are all specific for a given foreign microbial antigen, and furthermore, can “remember” a prior encounter with that antigen and effectively remove it much more quickly upon secondary exposure to the antigen. This phenomena is the basis for vaccination. Thus, aft

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Functional Role of Epitope Spreading in the Chronic Pathogenesis of Autoimmune and Virus-Induced Demoring the mechanisms by which infectious agents trigger autoimmune diseases is of great interest. Three mechanisms have been suggested to explain how a viral infection could lead to autoimmunity: viral . that nonspecifically lead to activation of autoreactive T cells (.); . between the pathogen and

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