Titlebook: Mechanisms of Lymphocyte Activation and Immune Regulation V; Molecular Basis of S Sudhir Gupta,William E. Paul,Roger M. Perlmutter Book 199

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Molecular and Genetic Insights Into T Cell Antigen Receptor Signal Transductiononse by T cells requires the recognition of antigen by the T cell antigen receptor (TCR) and the conversion of this recognition event into biochemical signals that can induce a cellular response. This cellular response leads to the clonal expansion of antigen-specific differentiated effector T cells

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Signal Transduction During T Cell Development to a membrane-proximal domain of MHC class II molecules on antigen presenting cells., while its cytoplasmic tail interacts with the cytoplasmic protein tyrosine kinase (PTK) p56. (lck), a member of the src family of protein tyrosine kinases (reviewed in reference 4). These properties of CD4 contrib

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Immunological Tolerance by Antigen-Induced Apoptosis of Mature T Lymphocytesically abrogate an immune response.. This form of acquired immunological tolerance can occur in adult animals and in certain circumstances has been shown to involve T lymphocytes. We have found conditions under which antigen causes the programmed death of mature T lymphocytes. We first determined th

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Properties of Ca Currents Activated by T Cell Receptor SignalingCa is a critical component of the signaling pathway because it helps to drive the cytoplasmic Ca from resting levels of around 100 nM up to several μM, the concentration required for activation of many intracellular Ca binding proteins and enzymes.. Recently there has been a great deal of progress i

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The Role of Syk in Cell Signaling This occurs even though the transmembrane components of the receptors themselves lack intrinsic enzymic activity. Instead, these receptors associate with and signal through cytoplasmic proteintyrosine kinases. These kinases are now known to include members of a new family of proteins for which the

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Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinasesult mammals) in the bone marrow. Three fundamental processes underlie lymphopoiesis. First, a small population of hematopoietic stem cells (estimated to represent something less than 0.1% of bone marrow cells) gives rise continuously to mature daughter cells through successive, self-regenerating cel

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