Titlebook: Mechanisms of Lymphocyte Activation and Immune Regulation V; Molecular Basis of S Sudhir Gupta,William E. Paul,Roger M. Perlmutter Book 199

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Brett A. Premack,Phyllis Gardnernt population are much slower than technological advances; nevertheless, those alterations take place as well. One of the major medical issues of our time, for example, is the changes in the immunological status of individuals. This issue influences the entire field of medicine, particularly oncolog

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Robert L. Geahlen,Debra L. Burgnt population are much slower than technological advances; nevertheless, those alterations take place as well. One of the major medical issues of our time, for example, is the changes in the immunological status of individuals. This issue influences the entire field of medicine, particularly oncolog

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Signaling and Internalisation Function of the B Cell Antigen Receptor Complexulin (mIg) and the disulfide-linked Ig-α and Ig-β heterodimer which is non-covalently associated with all classes of mIg molecules,. (for review see references 2–4). Ig-α and Ig-β are glycoproteins of Mr 34000 and Mr 39000,. which are encoded by the B-cell specific genes mb-1. and B29,. respectively

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B-Cell Activation by Wild Type and Mutant Ig-β Cytoplasmic Domainsto intracellular signalling molecules. We constructed chimeric genes encoding the extracellular and transmembrane domain of human CD8α and the cytoplasmic domain of Ig-α or Ig-β and examined the ability of the chimeric proteins to induce signalling in the murine B-cell lymphoma A20. Crosslinking of

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Accessory Molecules that Influence Signaling Through B Lymphocyte Antigen Receptorss of the Igα (CD79a, mb1) and Igβ (CD79b, B29) phosphoglycoproteins. Recent reviews detail pertinent findings on the BCR complex.. The structure of the BCR complex and some cell-surface molecules that influence signaling via the BCR are shown in Figure 1. The clonotypic Ig receptor has only a very s