| 书目名称 | Mechanisms of Genome Protection and Repair |
| 编辑 | Dmitry O. Zharkov |
| 视频video | |
| 概述 | DNA repair, the topic of this book, helps each human cell to survive millions of hits damaging its genome daily.Covers many levels, from single proteins at an atomistic resolution to whole organisms.F |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | DNA is under constant challenge from environmental and endogenous metabolic assaults. Several layers of defence and repair systems allow cells to maintain stable genomes; in humans, dysfunction of these systems leads to cancer, neurodegeneration, and other pathologies. At the same time, recently it had emerged that targeted and regulated DNA damage and repair is a mechanism underlying several important cellular processes such as epigenetic demethylation and immunoglobulin gene diversification. The present collection of papers is aimed to cover new developments in the area of protective and regulatory mechanisms associated with DNA damage. The mechanisms ruling the recognition of damaged nucleotides against the vast background of normal ones are reviewed. The role of extended non-catalytic domains that are often found in eukaryotic DNA repair proteins in contrast to their downsized, catalytic-only bacterial counterparts is discussed. Among the proposed subjects are the regulatory functions of bulky covalent modifications such as poly(ADP)ribosylation and ubiquitylation in DNA damage response, especially in the context of chromatin remodelling. As opposed to DNA repair, damage tolera |
| 出版日期 | Book 2020 |
| 关键词 | DNA damage; DNA repair; DNA tolerance; Cell response; Signaling pathway; Oxidative stress |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-030-41283-8 |
| isbn_softcover | 978-3-030-41285-2 |
| isbn_ebook | 978-3-030-41283-8Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
发表于 2025-3-21 19:55:04
