Titlebook: Mechanism of Action of Antimicrobial and Antitumor Agents; John W. Corcoran,Fred E. Hahn,K. L. Arora Book 1975 Springer-Verlag Berlin Heid

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Bleomycind B.. Among these, the structures of copper-free bleomycins A., demethyl-A., A., A.′-a, A.′-b, A., A., B. and B. have been studied. These bleomycins are different from one another in the terminal amine moiety as shown in Table 1 (., 1971). ... (1972b), proposed the structures as shown in Fig. 1.

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Chloroquine (Resochin)oxy-phenyl group. Chloroquine might also be considered a position isomer of pamaquine (Plasmochin), an 8-aminoquinoline (., 1932), although the electronegative substituent, −OCH., in pamaquine occupies position 6 (rather than 7) of the quinoline ring system.

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Distamycin A and Netropsinot asymmetrically perturbed but more precise information on the configuration of distamycin A in physiological solution is lacking. Experimental studies of the molecular pharmacology of distamycin A are hampered by the instability of the antibiotic.

Critical

Ethidium and Propidiumnly recently become of interest for its value in a procedure for the isolation of closed circular duplex DNA (see below). Consequently the bulk of this review will be concerned with ethidium, but reference will be made to the limited information about propidium where possible.

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Kanchanomycinn D. On the other hand, kanchanomycin has been found to have only slight or no antitumor activity against various transplanted tumors in rodents. In man, severe thromophlebitis at the site of intravenous injection has limited extensive clinical trials.

Ancillary

PARA

Book 1975Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the

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