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Titlebook: Manual of Biological Markers of Disease; W. J. Venrooij,R. N. Maini Book 1996 Springer Science+Business Media Dordrecht 1996 Antigen.Arthr

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Enzyme-linked immunosorbant assay in the rheumatological laboratoryl diseases has led to the development of assay systems which are proving to be of great utility. Unfortunately, in practice, the results do not always match the high standards which are appropriate for use in routine diagnosis or application in research. In this paper we offer guidelines on practica
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Immunoprecipitation of labelled proteinsre components of subcellular particles (for review see [1]). These subcellular particles frequently comprise aggregates of several different proteins, with or without different species of RNA. Specific immunoprecipitation using a defined autoantibody, therefore results in the precipitation of not on
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Measurement of antibodies to DNAs disease, which makes their detection an important diagnostic aid to the clinician. Fluctuations in the level of anti-dsDNA in an individual patient generally parallel the clinical status of that patient. Furthermore, the presence of anti-dsDNA may precede the diagnosis of SLE by more than a year.
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Methods to detect autoantibodies to neutrophilic granulocytes[1, 2]. Although recognized as early as 1973 [3], autoantibodies to cytoplasmic antigens of neutrophils were not described in literature until 1982 [4]. The morphology and content of a granulocyte is given in Fig. 1. Autoantibodies to surface components of neutrophils are considered to be extremely
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Detection of antiperinuclear factor and antikeratin antibodiestablished and depends mainly on the presence of rheumatoid factors (RF). A positive RF test has a predictive value [1] and is related to disease with a more severe outcome [2]. However, RF is also present in other (autoimmune) diseases and in control sera from healthy people [3]. Therefore, testing
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Standards and reference preparationsince the methods to demonstrate the antibodies mentioned in this manual are, at most, about the same but never exactly equal to each other in distinct laboratories, the need for standardization is often urgently felt as soon as a new method becomes generally used [1–9]. Often the first idea is then
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E. M. Tanor the first Session. That is the social economical background. I think that even in mathematics this background is of greatest importance, not only for the early development of mathematics but also for the tremendous achievements and new mathematical ideas in our century. I claim that basically the
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