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Titlebook: Managing BRCA Mutation Carriers; Anees B. Chagpar Book 2017 Springer International Publishing AG 2017 Pathology of BCRA.DNA damage repair.

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Surgical Management of Breast Cancer in , Mutation Carriers,es. This recognition has led to many questions regarding the optimal surgical management for those considered to be high risk. There is no consensus on what constitutes the best surgical management of primary breast cancer in. mutation carriers. Several aspects need be considered during the surgical
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Radiation Oncology Considerations in the Management of Mutation Carriers with Breast Cancer,cer with TNBC, present guidelines for genetic screening suggest that all TNBC patients younger than 60 years, irrespective of family history, should be considered for genetic testing. Though genetic status will ultimately guide in the local treatment management decisions, the long-term implications
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Fertility Preservation in , Carriers: Special Considerations,ntries, women under the age of 45 are more likely to die of breast cancer than of any other disease or injury [.]. Women with hereditary breast and ovarian cancer syndromes, including carriers of deleterious mutations in the . or . genes, not only are at approximately fivefold increased risk of brea
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Management of Male , Mutation Carriers,t cancer and 5–10% are associated with germline cancer susceptibility gene mutations. Unfortunately, with such small numbers, the research opportunities and data available on the biology, diagnosis, and management of male breast cancer have been limited. The management of male breast cancer, therefo
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Psychosocial, Ethical, and Legal Implications for Mutation Carriers,th hereditary breast and ovarian cancer (HBOC) syndrome due to inherited . and . gene mutations. While cancer risk may be mitigated by enhanced surveillance, chemoprevention, and/or risk-reducing surgery, careful attention must be paid to psychosocial aspects of genetic testing, risk communication w
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