Titlebook: Malaria Control and Elimination; Frédéric Ariey,Frédérick Gay,Robert Ménard Book 2019 Springer Science+Business Media, LLC, part of Spring

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Diagnosing Malaria: Methods, Tools, and Field Applicabilityent diagnostic approaches currently in use or under testing for use in case management and/or epidemiological studies of malaria. Emphasis is laid on the basic principles of each diagnostic approach as well as their operational limits under different malaria endemicity settings. The discussed method

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Serological Profiling for Malaria Surveillance Using a Standard ELISA Protocolns in biological samples. For analysis of specific antibodies in serum, a capture antigen is immobilized onto a solid polystyrene surface from which it can capture the antibodies. The captured antibodies are subsequently detected using a secondary antibody conjugated to an enzyme. Detection is accom

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Controlled Human Malaria Infection (CHMI) Studies: Over 100 Years of Experience with Parasite Injectorous screening, volunteers are inoculated with . sporozoites or blood stages and monitored under strict clinical supervision until they are treated with a licensed malaria drug and the infection is completely resolved. Historically, experimental . challenge infections were applied to confirm that .

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Vaccine Development: From Preclinical Studies to Phase 1/2 Clinical Trialslong process involving several stages. During all developmental phases, priority is the safety of the new product, which is often used in young infants. The initial research phase lasts 1–5 years and is followed by a clinical and pharmaceutical development phase (preclinical and clinical phases), wh

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