Titlebook: Malaria; Immune Response to I Maria M. Mota,Ana Rodriguez Book 2017 Springer International Publishing Switzerland 2017 Immunology.Malaria.P

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Subunit Blood-Stage Malaria Vaccinesmalaria disease, resulting from control of the parasite’s asexual blood-stage. This has for many years been viewed as a ‘proof-of-concept’ encouraging the development of blood-stage vaccines (BSVs). Results of clinical trials of candidate subunit BSVs have mostly, however, not lived up to early expe

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https://doi.org/10.1007/978-3-319-45210-4Immunology; Malaria; Plasmodium; Vaccine; Vector; vaccines; infectious diseases

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Book 2017towards implementing andcoordinating efforts to eradicate this disease. An effective malaria vaccine isrecognized as the key element that will decide between success and failure inthis fight. At present, despite intensive research efforts, such a vaccine isnot yet available for use. However, there a

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Innate Immunity to Malariading the host innate immune response to a . liver and blood-stage infection, focusing on the different parasite- and host-derived molecules that trigger inflammation, the immune cell types involved, and the role of different cytokines in inflammation and pathology of malaria.

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Viral Vector Vaccines for Liver-Stage Malariap for possible prime-boost heterologous immunization regimens utilizing both RTS,S and viral-vectored malarial vaccines. This chapter will review the research regarding the development of viral-vectored vaccines against the liver stages of malaria from small animal and nonhuman primate models to humans.