Titlebook: Make Life Visible; Yoshiaki Toyama,Atsushi Miyawaki,Masahiro Jinzaki Conference proceedings‘‘‘‘‘‘‘‘ 2020 The Editor(s) (if applicable) and

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19F MRI Probes with Tunable Chemical Switcheses could not be applicable to in vivo applications owing to low sensitivity. Though PFC encapsulated nanoparticle are highly sensitive, activatable PFC encapsulated nanoparticles (switching OFF/ON-type probes) have not been reported. Thus, activatable PFC nanoparticles are highly desirable in order

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Circuit-Dependent Striatal PKA and ERK Signaling Underlying Action Selectionl, Annu Rev Neurosci, 2008). Striatal transmission is mediated by two distinct neuronal subpopulations consisting of D1 and D2 receptor-expressing medium spiny neurons (dMSNs, iMSNs) and is regulated by protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) cascades (Luo et al., J. N

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Making Life Visible: Fluorescent Indicators to Probe Membrane Potentialnvironment. Far from a passive bystander, the lipid membrane plays an active role in sequestering and accumulating genetic material, proteins, nutrients and ions essential for life. Indeed, cells allocate a significant portion of their energy budget to maintain an unequal distribution of ions across

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Molecular Dynamics Revealed by Single-Molecule FRET Measurementules. Among the single-molecule imaging techniques, fluorescence resonance energy transfer (FRET) measurement is relatively easy to set up, yet is a powerful method; it can visualize substrate binding and dissociation as well as intramolecular structural changes within a single molecule in real time

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Visualization of the Pathological Changes After Spinal Cord Injury (,)y reported the effectiveness of cell transplantation for SCI animal models, which was confirmed with behavioral and histological examinations. In terms of clinical application, we have to replace the histological examinations as imaging examinations. In this chapter, I introduced our recent progress

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Visualizing the Immune Response to Infectionson of immune cells and highly dynamic interactions of the migrating cells with their environment. Lymph nodes play a central role in this process by acting as local filter stations that prevent the spread of invading microbes and by providing a sophisticated environment to initiate and regulate inna