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Titlebook: Macropinocytosis; Functions and Mechan Cosimo Commisso Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license t

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书目名称Macropinocytosis
副标题Functions and Mechan
编辑Cosimo Commisso
视频video
概述Sheds light on the importance of macropinocytosis in health and disease.Provides an overview of the molecular mechanisms underlying macropinocytosis.Covers the functional aspects of macropinocytosis f
丛书名称Subcellular Biochemistry
图书封面Titlebook: Macropinocytosis; Functions and Mechan Cosimo Commisso Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license t
描述.This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process..Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students..
出版日期Book 2022
关键词Macropinocytosis; Endocytosis; Vesicles; Intracellular trafficking; Exocytosis; Lysosomes; Antigen present
版次1
doihttps://doi.org/10.1007/978-3-030-94004-1
isbn_softcover978-3-030-94006-5
isbn_ebook978-3-030-94004-1Series ISSN 0306-0225 Series E-ISSN 2542-8810
issn_series 0306-0225
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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Macropinocytosis978-3-030-94004-1Series ISSN 0306-0225 Series E-ISSN 2542-8810
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Functional Diversity of Macropinocytosisn be exploited to develop novel therapeutic targets. In this chapter, we discuss the different molecular mechanisms that initiate the process of macropinocytosis with special emphasis on proteins involved and their diversified role in different cell types.
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Signaling Pathways that Regulate Macropinocytosis in Mammalian Cellscluding several nutrient-sensing and developmental signaling pathways. Many of these signaling pathways have proto-oncogenic properties, and their dysregulation drives the high macropinocytic activity that is commonly observed in cancer cells. These regulatory principles illustrate how macropinocyto
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