Titlebook: Macropinocytosis; Functions and Mechan Cosimo Commisso Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license t

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Roles for 3’ Phosphoinositides in Macropinocytosis and transitions between those stages. Each stage in the process is regulated by variously phosphorylated derivatives of phosphatidylinositol (PtdIns) which reside in the cytoplasmic face of the membrane lipid bilayer. PtdIns derivatives phosphorylated at the 3’ position of the inositol moiety, call

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KRASG12R-Independent Macropinocytosis in Pancreatic Cancerch activates the PI3Kα lipid kinase and RAC1, to drive membrane ruffling, macropinosome uptake and processing. However, our recent study on the KRAS. mutant indicated the presence of a KRAS-independent mode of macropinocytosis in pancreatic cancer cell lines, thereby increasing the complexity of thi

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