| 书目名称 | Macrophages: Biology and Role in the Pathology of Diseases | | 编辑 | Subhra K. Biswas,Alberto Mantovani | | 视频video | | | 概述 | Presents an updated view of the field which has undergone a significant evolution and new understanding in the last 10 years.Comprehensively covers new areas of monocyte/macrophage research like polar | | 图书封面 |  | | 描述 | .Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells..Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrop | | 出版日期 | Book 2014 | | 关键词 | disease; homeostasis; immune system; inflammation; macrophages; microenvironment; antibodies | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4939-1311-4 | | isbn_softcover | 978-1-4939-5487-2 | | isbn_ebook | 978-1-4939-1311-4 | | copyright | Springer Science+Business Media New York 2014 |
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发表于 2025-3-21 18:42:13
