Titlebook: Machine Learning and Knowledge Discovery in Databases: Applied Data Science Track; European Conference, Yuxiao Dong,Dunja Mladenić,Craig Sa

Obstacle

Junhua Liu,Kristin L. Wood,Kwan Hui Lim LRRK2 is comparatively quite low in ventral midbrain dopaminergic neurons, the possibility exists that non-cell autonomous signaling also contributes to the loss of these neurons. In this chapter, we will discuss the different neuronal death pathways that may be activated by mutant forms of LRRK2,

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ervation. Development of more sensitive biomarkers to identify mutation carriers at risk of developing PD, as well as biomarkers of disease progression among . carriers with PD, is required. Such biomarkers would help evaluate interventions, which may prevent PD among non-manifesting carriers, or sl

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Roghayeh Mojarad,Ferhat Attal,Abdelghani Chibani,Yacine Amiratss attention. The GTPase domain has been shown to play an important role in regulating kinase activity, in dimerization, and in mediating the neurotoxic effects of LRRK2. Accordingly, the GTPase domain has emerged as a potential therapeutic target for inhibiting the pathogenic effects of LRRK2 mutat

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DEAF

Seoyoung Park,Siho Han,Simon S. Woolar counter receptor, E-selectin (CD62E), which is expressed on inflamed superficial dermal postcapillary venules and endothelial cells (Picker et al. 1991; Rossiter et al. 1994). CLA. CD45RO. T cells migrate across activated endothelium using CLA/E-selectin, VLA-4/VCAM-1, and LFA-1/ICAM-1 interacti

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Collected

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Taofeng Xue,Xinzhou Dong,Wei Zhuo,Beihong Jin,He Chen,Wenhai Pan,Beibei Li,Xuejian Zhang