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Titlebook: MIF Family Cytokines in Innate Immunity and Homeostasis; Richard Bucala,Jürgen Bernhagen Book 2017 Springer International Publishing AG 20

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书目名称MIF Family Cytokines in Innate Immunity and Homeostasis
编辑Richard Bucala,Jürgen Bernhagen
视频video
概述Provides a comprehensive synthesis of the state-of-the-art of MIF science.Covers role of MIF in immunopathogenesis of different inflammatory, autoimmune, and infectious diseases.Provides outlook on MI
丛书名称Progress in Inflammation Research
图书封面Titlebook: MIF Family Cytokines in Innate Immunity and Homeostasis;  Richard Bucala,Jürgen Bernhagen Book 2017 Springer International Publishing AG 20
描述The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses.  MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized.  MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.
出版日期Book 2017
关键词Infectious Diseases; MIF Biology; MIF-directed therapies; MMIF; Macrophage Migration Inhibitory Factor (
版次1
doihttps://doi.org/10.1007/978-3-319-52354-5
isbn_softcover978-3-319-84882-2
isbn_ebook978-3-319-52354-5Series ISSN 1422-7746 Series E-ISSN 2296-4525
issn_series 1422-7746
copyrightSpringer International Publishing AG 2017
The information of publication is updating

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Advances in Understanding the Role of MIF in the Pathogenesis of Autoimmune Diseases,ted in the pathogenesis of a variety of infectious, inflammatory, and autoimmune disease conditions including rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus. During autoimmune diseases, the overproduction of MIF may potentiate inflammation and priming of autoreactive cell
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MIF Family Proteins in Cardiac Ischemia/Reperfusion Injury,onse to environmental stress. In the heart, MIF is released by ischemic cardiomyocytes and acts by autocrine/paracrine signaling. Recent studies have identified a unique role for MIF as a local cardioprotective cytokine, which thus may be of particular relevance for patients exposed to myocardial I/
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MIF in Eosinophilic Inflammation,ed tissues. MIF also affects several aspects of eosinophil physiology including differentiation, survival, activation, and migration. In this chapter, we reviewed the current knowledge of the role of MIF in eosinophil biology and in eosinophilic inflammatory conditions.
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