| 书目名称 | MHC Class I Antigens In Malignant Cells |
| 副标题 | Immune Escape And Re |
| 编辑 | Natalia Aptsiauri,Angel Miguel Garcia-Lora,Teresa |
| 视频video | |
| 概述 | Discusses molecular mechanisms of total or partial loss of the MHC class I antigens in cancer cells.Explains the role of MHC class I defects in cancer progression.Shows the correlation of MHC class I |
| 丛书名称 | SpringerBriefs in Cancer Research |
| 图书封面 |  |
| 描述 | Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunothe |
| 出版日期 | Book 2013 |
| 关键词 | Immunotherapy; MHC class I; cancer; immune escape; metastasis; tumor rejection |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-6543-0 |
| isbn_softcover | 978-1-4614-6542-3 |
| isbn_ebook | 978-1-4614-6543-0Series ISSN 2194-1173 Series E-ISSN 2194-1181 |
| issn_series | 2194-1173 |
| copyright | Maria Teresa Cabrera Castillo 2013 |
发表于 2025-3-21 16:15:32
