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Titlebook: Lymphocyte Stimulation; Differential Sensiti Amleto Castellani Book 1980 Springer Science+Business Media New York 1980 DNA.biology.cell.cel

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书目名称Lymphocyte Stimulation
副标题Differential Sensiti
编辑Amleto Castellani
视频video
图书封面Titlebook: Lymphocyte Stimulation; Differential Sensiti Amleto Castellani Book 1980 Springer Science+Business Media New York 1980 DNA.biology.cell.cel
描述This book is a collection of some of the papers presented at the EMBO Lecture Course on "Lymphocyte stimulation: differential sensitivity to radiation; biochemical and immunological properties." The Course was organized with the aim of fostering interactions between photoradiobiologists and immunologists interested in the problem of DNA damage and repair studied at the lymphocyte level. The papers presented in this book are mainly centered on the problem of radiation sensitivity of lymphocytes in relation to DNA repair phenomena. The radiation biology of human lymphocytes is dominated by two phenomena: (a) high radiosensitivity of lymphocytes which die in interphase (b) PHA-induced relative radioresistance of those cells which, after stimulation, escape the interphase death and eventually die in mitosis. These phenomena constitute a good system to study some of the factors which control the response of human cells to irradiation. In addition it is possible to correlate the development of the relative radioresistance in PHA-stimulated lymphocytes with the biochemical changes connected with the transformation processes. The papers presented in this book constitute a real contribution
出版日期Book 1980
关键词DNA; biology; cell; cells; death; development; immunology; lymphocytes; radiation; research; resistance
版次1
doihttps://doi.org/10.1007/978-1-4684-6997-4
isbn_softcover978-1-4684-6999-8
isbn_ebook978-1-4684-6997-4
copyrightSpringer Science+Business Media New York 1980
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,Functions of DNA Polymerases α, β and γ in DNA Replication and Repair,f their activities is easily obtained by utilizing the differences in molecular weight, sensitivity to inhibitors, chromatographic elution, ability to copy various templates (reviews: 2–8). The general properties of the three enzymes are summarized in Table I.
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Enzymes from Calf Thymus That Might Be Involved in DNA Repair,ell transformation that will eventually lead to cancer. Radiation and substances that directly or indirectly alter the molecules of DNA are potentially mutagenic and carcinogenic, thus behaving as genetic toxins. Detrimental agents of this type are natural or artificial components of the environment in which we all presently live.
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Thymocyte Maturation Induced by a Cyclic AMP-Elevating Thymic Factor,s in thymocytes. By means of direct measurement of intracellular cAMP in human and mouse thymocytes ., we demonstrated the existence in human serum of a thymus-dependent factor (SF) (7) which has the capacity to increase cAMP levels.
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radiation; biochemical and immunological properties." The Course was organized with the aim of fostering interactions between photoradiobiologists and immunologists interested in the problem of DNA damage and repair studied at the lymphocyte level. The papers presented in this book are mainly cente
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DNA Repair in Some Cancer-Prone Conditions and in Patients with Cutaneous Malignancies, they are not able to restore the original DNA molecule without causing errors in the DNA sequence, mutations and neoplasms may result (5). Thus, DNA repair mechanisms should be considered as important biological defence mechanisms against mutagenic and carcinogenic events.
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978-1-4684-6999-8Springer Science+Business Media New York 1980
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