Titlebook: Lymphocyte Activation and Immune Regulation IX; Homeostasis and Lymp Sudhir Gupta,Eugene Butcher,William Paul Book 2002 The Editor(s) (if a

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Self-Recognition and the Regulation of Cd4+ T Cell Survivalure, we conclude that essentially all previous claims that MHC class II recognition plays a significant role in the survival of CD4+ T cells can be reinterpreted as an effect of self-recognition on proliferation in lymphopenic environments, maintaining population numbers without a marked effect on i

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Tcr-Independent Proliferation and Differentiation of Human Cd4+ T Cell Subsets Induced by Cytokinese-expanded naïve T cells maintain a naïve phenotype, memory cells differentiate acquiring new effector functions and switching expression of chemokine receptors. Thus human naive and memory T cell pools can be maintained with homeostatic cytokines in the absence of TCR stimulation.

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