Titlebook: Lymphocyte Activation and Immune Regulation IX; Homeostasis and Lymp Sudhir Gupta,Eugene Butcher,William Paul Book 2002 The Editor(s) (if a

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Homeostatic Chemokines and the Targeting of Regional Immunityiscovery of several related epithelial-expressed chemokines (TECK/CCL25 in small intestine, CTACK/CCL27 in skin, and MEC/CCL28 in diverse mucosal sites) now highlights an important role for epithelial cells in controlling homeostatic lymphocyte trafficking, including the localization of cutaneous an

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Neonates Support “Homeostatic” Proliferationher antigenic challenge or lymphoablative therapies lead to activation of homeostatic regulatory processes including massive activation-induced cell death and homeostatic proliferation of peripheral T cells, respectively (Marrack et al., 2000). Experimentally, it has been well demonstrated that lymp

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Self-Recognition and the Regulation of Cd4+ T Cell Survivalds on adequate but not excessive signaling upon T cell receptor (TCR) engagement of selfpeptide/MHC class II molecule ligands present in the thymic environment. Persistent TCR signaling throughout development from the CD4+CD8+ to the CD4+ state is required for completion of the developmental process

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Tcr-Independent Proliferation and Differentiation of Human Cd4+ T Cell Subsets Induced by Cytokines tickling by self-MHC for homeostatic proliferation in lymphopenic mice, memory cells do not but respond to cytokines. Human naïve and memory CD4.T cell subsets can be selectively expanded . with different cytokine combinations. Responsiveness of T cells to homeostatic cytokines is associated with t

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Some Properties of T Cells in Animalsncerns the fact that T cells divide in the apparent absence of antigen when transferred to T cell deficient mice. The second investigates the finding that memory T cells contain very large amounts of mRNA for certain chemokines. These two phenomena will be discussed in separate sections below.