Titlebook: Local Immunosuppression of Organ Transplants; Scott A. Gruber Book 1996 Springer-Verlag Berlin Heidelberg 1996 drug.drug delivery.drug dev

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Intraportal Cyclosporine A in Canine Liver Transplantationver transplantation., early postoperative complications such as acute rejection and infection are still the major causes of morbidity and mortality.. In addition, adverse effects of immunosuppressants such as nephrotoxicity due to CsA and deterioration of systemic immune function restrict the permissible dosage of these drugs..

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978-3-662-22107-5Springer-Verlag Berlin Heidelberg 1996

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Local Immunosuppression of Organ Transplants978-3-662-22105-1Series ISSN 1080-3645

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Intraportal Delivery of Immunosuppressants to Intrahepatic Islet Allograftsd cells returning to the graft and destroying cells bearing foreign histocompatibility antigens. Nonspecific immunosuppressive agents, such as azathioprine and steroids, interfered with proliferating cells in the spleen and other lymphoid depots. Given this schema, the value of immunosuppression at the graft site was doubtful.

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Book 1996pressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields of transpl

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1080-3645 immunosuppressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields

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Cyclosporine Aerosol in Lung Transplantationonal route is well developed for other pulmonary disorders. In 1988, a team of investigators at the University of Pittsburgh made the decision to pursue aerosolized immunosuppression for lung transplant recipients based upon the success of other experimental models of localized immunosuppression.