Titlebook: Liquid Biopsy in Cancer Patients; The Hand Lens for Tu Antonio Russo,Antonio Giordano,Christian Rolfo Book 2017 Springer International Publ

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Tissue Versus Liquid Biopsy: Opposite or Complementary?,of the tissue (i.e., dysplasia) are funding elements in the diagnosis of malignancies, yet the pieces of information conveyed by these features are often insufficient for the precise identification of a specific cancer histotype, and sometimes they prove faulty [1–6].

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Liquid Biopsy in Gynecological Cancers,ent-resistance in gynecological cancer patients. The ability to detect circulating tumor DNA (ct-DNA), Exosome and Circulating miRNA, as novel molecular biomarkers is possible thanks to the advent of novel high throughput sequencing technologies and new analytical techniques, which favoured the spreading of the personalized medicine worldwide.

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Technical Aspects for the Evaluation of Circulating Nucleic Acids (CNAs): Circulating Tumor DNA (ctst sources for CNAs due to the very simple and minimally invasive way of sampling. Moreover, it can be repeated at different time points, giving the opportunity for a real-time monitoring of the disease.

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Technical Aspects for the Evaluation of Exosomes and Their Content,tic application. This chapter focuses on the isolation and study of exosomes from liquid biopsies and summarizes the recent exosomal miRNA and protein profiling data supporting the potential role of tumor-derived exosomes as biomarkers and their potential application in clinical settings.

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2197-781X nding field of “liquid biopsy” for the management of cancer This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of “liquid biopsy” for the management of cancer patients. The liquid biopsy repr

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Book 2017ing field of “liquid biopsy” for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our “hand lens” to follow molecular changes that characterize tumor development and pr

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Liquid Biopsy in Cancer Patients: The Hand Lens to Investigate Tumor Evolution,elopment and progression. Several tumors are defined as “oncogene addicted” and this discovery has led the way to the development of target therapies that are able to specifically kill cancer cells sparing normal cells from toxicity. Nowadays treatment decision is strictly dependent on the molecular

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