Titlebook: Liposome Dermatics; Griesbach Conference Otto Braun-Falco,Hans Christian Korting,Howard I. Conference proceedings 1992 Springer-Verlag Ber

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https://doi.org/10.1007/978-3-642-48391-2Arzneimittelträger; Dermatotherapy; Drug Carrier System; Hautkrankheiten; Liposom; Liposome; Topical Drug;

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Liposome Production: Historic AspectsNowadays it is clear that liposomes have become a reality in cosmetics [19, 29] and in dermatology (this volume). Also, the multitude of ongoing clinical trials with various liposome-based formulations is an indication that at least some liposomal formulatons may become pharmaceutical dosage forms for clinical use [21, 39].

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Liposome Production: The Ethanol Injection Technique and the Development of the First Approved LiposIn 1984, the CILAG company initiated the practical development of a liposome dermatic containing 1% of the antifungal econazole. Driven by the hypothesis that liposomally entrapped econazole might have beneficial clinical properties, focus was first directed towards finding a manufacturing technique with the potential for economic scale-up.

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Properties and Characterization of Pre-Liposome SystemsThe requirements of a liposomal system for skin treatment are varied. In addition to the advantage of being able to offer an innovative system, the following functions have been specified to date:

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Griesbach Konferenz‘ Griesbach Conferencehttp://image.papertrans.cn/l/image/586913.jpg

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Percutaneous Absorption and Conventional Penetration Enhancers constant. For almost a century, it has been known that the applied vehicles influence transdermal absorption [2]; nevertheless, the mechanisms causing the changes in permeability are still today not understood in every respect. Important ideas concerning this problem are based on the progress in th