Titlebook: Linear Aggregation Theory in Cell Biology; Terrell L. Hill Book 1987 Springer-Verlag New York Inc. 1987 biology.cell.cell biology.molecula

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Statistical Thermodynamic Backgrounds between protein molecules). This is the simplest case and is the subject of Part I of this book. Part II treats “steady-state aggregates.” This term refers to cases in which the monomers are enzyme molecules and a chemical reaction, catalyzed by the aggregated enzyme, accompanies or follows monome

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Single-Stranded Polymer Modified by a Second Component, a Bound Ligand, or a Cap In Section 10, the “second molecule” is a second component that aggregates along with the first component. In Section 11, the “second molecule” is a ligand that binds to the aggregating species all along the polymeror, in other cases, the ligand binding is confined to the ends of the polymer. Secti

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Enzymatic Activity at Polymer Tips Only These are termed “equilibrium aggregates.” Chapters 7 and 8 are more complicated in that we study the aggregation of . molecules: in addition to the intermolecular (i.e., interenzyme) forces that produce the aggregation, the subunits of the polymer may be engaged in enzymatic activity. Such polymer

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NTP Caps and Possible Phase Changes at Polymer Endsrotubules were believed, at one time, to behave in this relatively simple way. As of this writing, it seems clear that, in both cases, NTP subunits actually penetrate (or survive) into the polymer ends by virtue of addition of subsequent subunits: conversion of an added NTP subunit into an NDP subun

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Attached Single-Stranded Polymeres a 1-start, 2-strand helical structure (as in actin) and Fig. 2-1 (c) shows a 1-start, 3-strand helical structure (flattened). In the limiting case just mentioned, both structures would behave kinetically like a single helix (i.e., in effect, a single strand). This would be true of any 1-start tub

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NTP Caps and Possible Phase Changes at Polymer Endshavior at the polymer ends. The two phases referred to are a polymer end either with or without an NTP cap. This subject can be dealt with without a commitment to a particular detailed biochemical model; we merely assume that some unspecified biochemical mechanism exists that generates two-phase act