| 书目名称 | Leukotrienes | | 副标题 | New Concepts and Tar | | 编辑 | Ian Rodger,Jack Botting,Sven-Erik Dahlén | | 视频video | | | 图书封面 |  | | 描述 | In the two decades since the elusive "slow reacting substance of anaphylaxis" (SRS-A) was identified as a product of the action of the 5-lipoxygenase enzyme on arachidonic acid, it has been well established that the leukotrienes are key mediators of both alIergy and inflammation. Their release by alIergen or other challenge has been demonstrated in the lungs of asthmatic subjects, and measurement of urinary leukotriene concentrations in such patients has been shown to be a valuable, non invasive indicator. Significant progress has been made towards the characterization of the leukotriene receptor subtypes, exemplified by the cloning of the LTB4 receptor earlier this year. Coupled with this there has been a continued elucidation of signal transduction mechanisms underlying receptor activation. Consequent upon these advances has been the development of potent antagonists of the CysLT receptor, J and both these and inhibitors of leukotriene biosynthesis have entered clinical practice in the therapy of asthma. In this clinical setting antagonists of the CysLTJ receptor have been shown to be an effective therapy in chronic asthmatics, against antigen- and exercise-induced bronchoconstr | | 出版日期 | Book 1998 | | 关键词 | asthma; cardiovascular disease; inflammation; research | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-011-4880-1 | | isbn_softcover | 978-94-010-6045-5 | | isbn_ebook | 978-94-011-4880-1 | | copyright | Springer Science+Business Media Dordrecht 1998 |
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发表于 2025-3-21 18:10:18
