Titlebook: Leukemia Stem Cells in Hematologic Malignancies; Haojian Zhang,Shaoguang Li Book 2019 The Editor(s) (if applicable) and The Author(s), und

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DNA Damage Response in Quiescent Hematopoietic Stem Cells and Leukemia Stem Cells,the maintenance of normal stem cell poor for whole-life blood regeneration and the transformation to leukemia stem cells (LSCs) for leukemia initiation. LSCs also take actions of combating with the attack launched by externally therapeutic drugs that can kill most leukemic cells, to avoid exterminat

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Epigenetic Abnormalities in Acute Myeloid Leukemia and Leukemia Stem Cells,ulating data suggest that these leukemia-associated epigenetic factors play critical roles in both normal hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs). In turn, these abnormalities result in susceptibilities of LSC and related diseases to epigenetic inhibitors. In this chapter, we

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Cellular Immunotherapy in the Treatment of Hematopoietic Malignancies,ion of T cell cytotoxicity against tumors by adoptive cell therapies (ACT), cancer vaccines, gene therapies, and monoclonal antibody therapies has been intensively studied. In particular, immune checkpoint blockade and chimeric antigen receptor T (CAR-T) cell therapies are the recent clinical succes

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Lindsay M. Gurska,Kristina Ames,Kira Gritsman discuss and critique the role of formal science in restorat.Robert J. Cabin explores the relationship between science and practice in ecological restoration. Despite the often distinct cultures and methodologies of scientists and practitioners, Cabin shows how each has a vital role in effective res

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Dan Huang,Chiqi Chen,Xiaoxin Hao,Hao Gu,Li Xie,Zhuo Yu,Junke Zheng discuss and critique the role of formal science in restorat.Robert J. Cabin explores the relationship between science and practice in ecological restoration. Despite the often distinct cultures and methodologies of scientists and practitioners, Cabin shows how each has a vital role in effective res

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