Titlebook: LC-MS in Drug Analysis; Methods and Protocol Loralie J. Langman,Christine L.H. Snozek Book 2019Latest edition Springer Science+Business Med

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1064-3745 ation advice from the experts.This second edition provides detailed LC-MS(/MS) procedures for the analysis of compounds of clinical and toxicological significance. Chapters detail new and updated methods for analyzing drugs focusing on advances in technology, alternate matrices, and rapidly-changing

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Measurement of Buprenorphine and Norbuprenorphine in Urine,ed therapy programs for opioid dependency, as well as chronic pain management settings. Buprenorphine may also be included in drug testing programs for law enforcement purposes. The assay described here was designed to detect and quantify both buprenorphine and its metabolite norbuprenorphine.

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Salt-Assisted Liquid-Liquid Extraction of Meconium for Analysis of Cocaine and Amphetamines by Liqu the meconium matrix is not homogeneous and not easily mixed or extracted. A method for analyzing cocaine and metabolites as well as amphetamines in meconium utilizing ceramic homogenizers prior to salt-assisted liquid-liquid extraction and liquid chromatography tandem-mass spectrometry (LC-MS/MS) is presented.

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Simultaneous Determination of Tacrolimus and Cyclosporine A in Whole Blood by Ultrafast LC-MS/MS,stress on traditional technologies such as high-performance liquid chromatography-ultraviolet detection (HPLC-UV) and traditional LC-MS/MS. As an improvement to the existing methods, we describe a sensitive ultrafast LC-MS/MS with run times of less than 15 s per sample.

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Analysis of Synthetic Cannabinoid Metabolites by Liquid Chromatography-Tandem Mass Spectrometry,phase I metabolites and phase II conjugates. With proper knowledge of the correct analytical targets, relatively simple procedures are capable of extracting and analyzing synthetic cannabinoids. Following enzymatic hydrolysis, compounds can be extracted through liquid partitioning procedures, and the extracts are analyzed via LC-MS/MS.

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Drug Screening Using Liquid Chromatography Quadrupole Time-of-Flight (LC-QqTOF) Mass Spectrometry, collected in untargeted mode can be analyzed retrospectively to detect additional compounds that were not predefined targets. Much of the power of LC-QqTOF lies in data processing, and the data analysis workflow that a lab uses must be adequately validated.

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Book 2019Latest edition new and updated methods for analyzing drugs focusing on advances in technology, alternate matrices, and rapidly-changing classes of drugs of abuse, compounds pertinent to toxicology, and therapeutic agents. Written in the highly successful .Methods in Molecular Biology .series format, chapters incl