| 书目名称 | Kinetics of Enzyme-Modifier Interactions | | 副标题 | Selected Topics in t | | 编辑 | Antonio Baici | | 视频video | http://file.papertrans.cn/544/543070/543070.mp4 | | 概述 | Covers all known mechanisms of enzyme inhibition and activation.Only modern and robust methods are discussed.Includes step-by-step guided practical examples to accompany theoretical explanations.Shows | | 图书封面 |  | | 描述 | .The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous .species. in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms | | 出版日期 | Book 2015 | | 关键词 | Activation; Enzyme kinetics; Inhibition; Integrated rate equations; Simulation of dynamic processes; Prot | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-7091-1402-5 | | isbn_softcover | 978-3-7091-1949-5 | | isbn_ebook | 978-3-7091-1402-5 | | copyright | Springer-Verlag Wien 2015 |
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