Titlebook: Kinetic Data Analysis; Design and Analysis Laszlo Endrenyi Book 1981 Plenum Press, New York 1981 biochemistry.chemistry.data analysis.desi

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Experimental Designs for the Distribution-Free Analysis of Enzyme Kinetic Dataon the least-squares principle are appropriate when these errors follow a normal distribution but several studies have shown that, for enzyme kinetic measurements, such a distribution may not be common. Under these circumstances, distribution-free methods of analysis should be employed. In this pape

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A Priori Identifiability Analysis in Pharmacokinetic Experiment Designthe so-called identifiability problem which has to be faced .., once a certain pharmacokinetic model structure has been postulated and the input-output experiment planned, but prior to its performing. More precisely, identifiability analysis addresses the question of whether it is possible to obtain

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A Frequency Response Method for Pharmacokinetic Model Identificationto be useful for computation of the time course of systemic drug bioavailability. For linear compartment models the time course of either drug concentration or pharmacological response is represented by a sum of exponentials. The usual method for establishing such models involves the use of some for

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Some Current Problems in the Interpretation of Enzyme Kinetic Dataodels. The need for using experimental conditions reflecting those . when studying isolated enzymes is discussed. By now there is an extensive literature concerned with analyzing enzyme kinetic data. The consensus is that the traditional linearized methods yield inaccurate results, and that some for