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Titlebook: Kernicterus; David W. McCandless Book 2011 Springer Science+Business Media, LLC 2011

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,Crigler–Najjar Syndrome, patients were studied directly, one was in another hospital, and one was diagnosed by a careful history, but not examined by the authors. Complete genetic studies were not completed at the time of publication. It was suggested that 15 probable cases existed out of 105 family members over the six generations.
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Erythroblastosis Fetalis, and obvious way, hemolytic anemias in the newborn can be deleterious because they represent an increase in bilirubin formation at a time when the newborn liver may not be enzymatically equipped to conjugate the pigment, facilitating its excretion.
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Hyperbilirubinemia Revisited,d and conjugated bilirubin. It is assumed that in newborn infants the majority is unconjugated. Also not evaluated by either method is the contribution of “free” unbound to albumin bilirubin. It is this moiety of bilirubin, free and unbound to albumin which can move easily and rapidly into brain tissue.
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