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Titlebook: Ivermectin and Abamectin; William C. Campbell Book 1989 Springer-Verlag New York Inc. 1989 chemistry.crop protection.development.drug.fish

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书目名称Ivermectin and Abamectin
编辑William C. Campbell
视频video
图书封面Titlebook: Ivermectin and Abamectin;  William C. Campbell Book 1989 Springer-Verlag New York Inc. 1989 chemistry.crop protection.development.drug.fish
描述I.vermectin and .a.bamectin., members of the avermectin family of compounds, were introduced to the market in the 1980‘s as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.
出版日期Book 1989
关键词chemistry; crop protection; development; drug; fish; kinetics; medicine; metabolism; parasite; pesticide; phar
版次1
doihttps://doi.org/10.1007/978-1-4612-3626-9
isbn_softcover978-1-4612-8184-9
isbn_ebook978-1-4612-3626-9
copyrightSpringer-Verlag New York Inc. 1989
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Biosynthesisaccharide and possess a hydroxyl at either or both the C3” and C3’; desfurano avermectins lack the oxygen at C8a and C6 and possess a CH. at C8a and an H at C6; and 5-keto avermectins lack the hydroxyl (or methoxyl) at C5 and possess a keto group at C5.
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Safety of Ivermectin in Target Animalsd for safety by bridging studies involving assessment of tolerance and bioavailability. Control groups were given vehicle, saline, or left untreated; many studies included both treated and untreated controls.
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Environmental Aspects of Ivermectin Usage in Livestock: General Considerationsil and water. Additional studies investigated the drug’s effect on a variety of environmentally important organisms. These studies, combined with the clinical use pattern of ivermectin in cattle, sheep, and swine, provided the means to assess ivermectin’s environmental impact.
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Use of Ivermectin in Laboratory and Exotic Mammals and in Birds, Fish, and Reptiles, wild, zoo, and exotic mammals, as well as in reptiles, birds, and fish. Apart from domestic animals, ivermection has been approved by various regulatory authorities for use in camels and reindeer only. The treatment of any other species with the product is considered to be “extralabel” usage.
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Isolation and Characterization of the Producing Organismcin, and the thaimycins. Only hygromycin B has been used commercially; and, until the last decade, synthetic compounds dominated the anthelmintic market. The discovery of the avermectins changed that dramatically.
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Environmental Aspects of Abamectin Use in Crop Protection A chemical’s persistence is determined by its physicochemical properties: half-life in soil and water, photolytic stability, and soil-binding ability. These same factors also affect the chemical’s bioavailability to living organisms.
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