Titlebook: Ion Channels; Bernard Fermini,Birgit T. Priest Book 2008 Springer-Verlag Berlin Heidelberg 2008 Biomedicine.Medicinal Chemistry.Molecular

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Recent Advances in Ion Channel Screening Technologies, or mutant ion channel genes usingtraditional ion channel screening technologies. Therefore, several efforts were undertaken to automateand improve the throughput of electrophysiological methods. In this chapter, we will review a numberof the more standard ion channel screening technologies currentl

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Pharmacological Rescue of Mutant CFTR Function for the Treatment of Cystic Fibrosis, on their mode of action. The first class is known as CFTRcorrectors because they correct the processing and trafficking of CFTR to increases its cell surface density.The second class is known as CFTR potentiators as they potentiate the amount of anion secretion throughCFTR at the cell surface. In v

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On the Process of Finding Novel and Selective Sodium Channel Blockers for the Treatment of Diseaseseally suited for this task, and the recent development of automated electrophysiologyinstrumentation affords medium throughput. Higher capacity assays amenable to studying sodium channel pharmacologyinclude ligand binding, flux, and fluorescent assays.

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Kv1.5 Potassium Channel Inhibitors for the Treatment and Prevention of Atrial Fibrillation,inite proof of concept for Kv1.5 inhibition as an effective antiarrhythmic strategyawaits agents with greater Kv1.5 selectivity and a more detailed characterization of . .in human atria and the consequence of its inhibition.

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Book 2008target, the current status in the development of agents to treat the disease, and future prospects and challenges facing each therapeutic area. The reader will receive a critical overview covering the progress made in the rapidly developing and complex field of ion channels and diseases. .

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Fredrick Van Goor,Sabine Hadida,Peter Grootenhuisid Prototy ping“ ist die Zielsetzung des von der DFG geförderten Sonderforschungs bereichs 374, dessen Ergebnisse in diesem Band beschrieben werden.978-3-540-69880-7Series ISSN 2512-5281 Series E-ISSN 2512-529X

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