Titlebook: Inventing Reactions; Lukas J. Gooßen Book 2013 Springer-Verlag Berlin Heidelberg 2013 Allylic Alkylation.Amide Bond Formation.Carbene Cata

colony

,Catalysis: Unlimited Frontiers – Our Early Personal Journey into the World of Palladium,ne coupling and discovery of palladium complexes of trimethylenemethane as reactive intermediates for cycloadditions to five, seven, and nine membered carbo- and heterocycles. These new synthetic tools enabled facile strategies to complex structures possessing interesting properties, notably of biological relevance.

下垂

Reinventing Amide Bond Formation,catalysts, proceeds in the presence of unprotected functional groups, and generates no nonvolatile by-products. This chapter recounts our discovery of this reaction, our development of novel methods for the preparation of α-ketoacids and hydroxylamines, and the application of these new methods to the synthesis of peptides and proteins.

较早

出处

enfeeble

Gold-Catalyzed Organic Reactions,om gold to other transition metals, the development of new ligands for gold catalysis, and significant contributions from computational chemistry are other crucial points for the field highlighted here.

Ornament

Natural Products as Inspiration for Reaction Development: Catalytic Enantioselective Decarboxylativs in natural product synthesis. Finally, important contributions from other research groups involving related methods or products similar to the α-quaternary products that are the focus of our studies, as well as future directions for asymmetric alkylation reactions, are discussed.

弯曲的人

Incommensurate

Reinventing Amide Bond Formation,loped an amide-forming ligation reaction by the coupling of α-ketoacids and hydroxylamine (KAHA ligation). This reaction does not require reagents or catalysts, proceeds in the presence of unprotected functional groups, and generates no nonvolatile by-products. This chapter recounts our discovery of

放弃

歌唱队

The Interplay of Invention, Observation, and Discovery in the Development of Lewis Base Activation reactions with organosilicon nucleophiles. Prior to 2000, these reactions were exclusively practiced through the agency of highly electrophilic silicon species such as allyltrichlorosilanes and enoxytrichlorosilanes derived from aldehydes, ketones, and esters. However, a serendipitous discovery mad