Titlebook: Introduction to Evolutionary Genomics; Naruya Saitou Textbook 2018Latest edition Springer Nature Switzerland AG 2018 Bioinformatics.Evolut

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Textbook 2018Latest editionfundamental concepts in molecular biology and genome evolution for readers without any prior background in this area. This is followed by a detailed examination of genome evolution in various different groups of organisms. The text then concludes with a review of practical methods essential to resea

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Neutral Evolutionevolution, and amount of DNA variation kept in population. We then discuss various features of neutral evolution starting from evolutionary rates, synonymous and nonsynonymous substitutions, junk DNA, and pseudogenes.

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978-3-030-06478-5Springer Nature Switzerland AG 2018

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Introduction to Evolutionary Genomics978-3-319-92642-1Series ISSN 1568-2684 Series E-ISSN 2662-2432

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ProteinsCharacteristics of amino acids, building blocks of proteins, are first discussed, followed by discussions on protein structures and diversity of proteins. Gene family, super gene family, domains, and folds are discussed, and then, major categories of proteins are explained. Finally, history of protein study is discussed.

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MutationMutations, the fundamental sources of evolution, are discussed in detail. They include nucleotide substitutions, insertions/deletions, repeat number changes, recombinations, gene conversions, gene duplications, and genome duplications. Mutation rate estimates and methods to estimate mutation rates are also discussed.

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Virus GenomesClassification of viruses and phages is first given, followed by discussion on various RNA and DNA virus genomes.

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Homology Search and Multiple AlignmentHow to discover evolutionary homology of nucleotide and amino acid sequences and how to analyze these homologous sequences are discussed, including homology search, pairwise alignment, multiple alignment, and genome-wide sequence viewing.