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Titlebook: Introduction to Basics of Pharmacology and Toxicology; Volume 2 : Essential Abialbon Paul,Nishanthi Anandabaskar,Gerard Marsha Book 2021 Sp

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Cholinoceptor Agonists and Anticholinesterase Agentstransmitter of the parasympathetic system acting on muscarinic and nicotinic receptors. The cholinergic system can be directly stimulated by natural alkaloids like muscarine and nicotine, indirectly by inhibiting cholinesterase enzyme with carbamates. Toxins like bungarotoxins, conotoxin, and botuli
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Cholinoceptor Antagonistsnvented a series of anticholinergic drugs. A detailed study of the structure–activity relationship led to the development of tertiary and quaternary compounds with different pharmacokinetic properties. Antimuscarinic compounds are commonly used as antidotes in OPC poisoning, mydriatics, spasmolytics
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Adrenergic Agonistshe cardiovascular system maintaining the blood pressure and the heart rate. The primary neurotransmitters released by the adrenergic system are noradrenaline and adrenaline. These neurotransmitters have various functions on various organ systems depending on the receptor that is predominant at the t
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Adrenergic Antagonistsrbidity and mortality. Adrenergic antagonists block the action of catecholamines on the adrenergic receptors. Phenoxybenzamine and phentolamine are non-specific alpha blockers while prazosin and its derivatives block the alpha 1 receptors with some specificity. Alpha receptor blockade is particularl
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Neurotransmitters and Neurotransmission chemicals called neurotransmitters. Different neurotransmitters are expressed at a higher level in distinct areas of the brain signifying their physiological role. Various amino acids, amines, purines, gases, arachidonic acid derivatives, and peptides act as neurotransmitters. Additional compounds
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Pharmacotherapy of Seizureshe type of seizure and preexisting co-morbid conditions in the patient. Anti-seizure drugs generally act by reducing repeated neuronal firing by interacting with various types of neurotransmitters and ion channels. Most of the first line agents are metabolized by cytochrome P450 enzymes and also pla
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Drug Therapy of Psychosis and Maniaosis has not been confirmed, the dopaminergic theory still forms the frontline of management. Antipsychotic agents can be broadly divided into typical and atypical, mainly based on their affinity towards dopaminergic receptors. While the typical antipsychotics are still used in emergencies, the atyp
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