Titlebook: Interrelationship Among Aging, Cancer and Differentiation; Proceedings of the E Bernard Pullman,Paul O. P. Ts’o,Edmond L. Schneide Conferen

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Macromolecular Correlates of Cellular Senescence and Cancer,vel and in the 21 kd H-ras protein. Other genes, including α-hCG and N-myc, are not amplified in these cells. Methylation of cytosines in the γ-globin and a-hCG gene regions, assessed in fibroblast mass cultures and in derived clonal lineages, declined in a site-specific and clone-specific pattern.

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Arrhythmia

Retrovirus-Like Gene Families in Normal Cells: Potential for Affecting Cellular Gene Expression,lements, but are, neverthelsess, unrelated to retroviruses (i.e. there is no nucleic acid homology with known viruses). It has recently been shown that cellular retrovirus-like elements may occasionally act as natural mutagens. In order to assess the potential of retrovirus-like elements to affect e

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The Conformational Effects of UV Induced Damage on DNA,ructural models for photodamaged DNAs. Specifically, we present models both for a DNA molecule containing a psoralen photo-crosslink and for a DNA molecule containing a thymine photodimer. In both models, significant distortions of the nucleic acid helix are observed, including kinking and unwinding

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DNA Supercoiling and Gene Expression,s maintained by the actions of at least two DNA topoisomerases: an ATP-dependent enzyme DNA gyrase which reduces the linking number (negative supercoiling) and an ATP-independent enzyme DNA topoisomerase I which relaxes negatively supercoiled DNA. The expression of different genes is affected differ

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malapropism

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Jerusalem Symposiahttp://image.papertrans.cn/i/image/472807.jpg