Titlebook: International Symposium on Nicotine: The Effects of Nicotine on Biological Systems II; Satellite Symposium Paul Brian Sydenham Clarke,Mary

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Neuronal, trophic and endocrine effects of nicotinemilar roles in peripheral pathways, we have been able to demonstrate clear-cut functional deficits in cardiac-sympathetic activity in animals exposed to nicotine prenatally, characterized by deficiencies in sympathetic tone, in I3-adrenergic receptor binding sites and in heart rate responses to adre

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Nicotine and smoking: Current controversieson in both normal and pathological populations. Evidence indicates that the ability of smoking to affect brain function is response/task dependent and that evidence for both normalization and enhancement are observed with neuroelectric recordings.

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Nicotine and human diseasesoup of 30 patients who were intermittent smokers noted improvement of symptoms over six weeks while smoking twenty cigarettes daily. In attempts to identify the reason for benefit from smoking, nicotine has been tested formally using transdermal nicotine patches in a controlled trial involving 77 pa

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Receptor localizationrevious electron microscopic observations of Jacob and Berg (J. Neurosci. 3: 260–271, 1983) and Jacob et al. (PNAS 81: 3223–3227, 1984). A5-α7 dual labeling showed some areas of co-localization and others areas where each subunit LI was present in the absence of the other. Rhodamine-a-bungarotoxin c

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Receptor subtypes — Molecular biology and pharmacologyel which is activated by acetylcholine with an EC. of 10µM. While acetylcholine is a full agonist, both the nicotinic agonist DMPP and the muscarinic agonist oxotremorine-M are weak partial agonists. The receptor is not activated either by nicotine or by muscarine. However, both nicotine and muscari

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Effects on gene expression These results suggest that acute injections of nicotine induce intense Fos expression in two major areas of the rat hypothalamus, namely 1 the CRF neurons of the parvocellular paraventricular nucleus, an area of the hypothalamus recognized to mediate stress response and 2. the lateral preoptic area