| 书目名称 | Interleukin-27: Biological Properties and Clinical Application | | 编辑 | Marek Jankowski,Tomasz Wandtke | | 视频video | | | 概述 | Includes supplementary material: | | 丛书名称 | SpringerBriefs in Immunology | | 图书封面 |  | | 描述 | .This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.. | | 出版日期 | Book 2016 | | 关键词 | Cancer; Immunotherapy; Interleukin-27 receptor; Multiple sclerosis; Viral infections; Rheumatoid arthriti | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-39664-4 | | isbn_softcover | 978-3-319-39662-0 | | isbn_ebook | 978-3-319-39664-4Series ISSN 2194-2773 Series E-ISSN 2194-2781 | | issn_series | 2194-2773 | | copyright | The Author(s) 2016 |
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发表于 2025-3-21 17:54:26
