| 书目名称 | Interleukin Protocols | | 编辑 | Luke A. J. O’Neill,Andrew Bowie | | 视频video | | | 概述 | Includes supplementary material: | | 丛书名称 | Methods in Molecular Medicine | | 图书封面 |  | | 描述 | Interleukins are a family of proteins that regulate the maturation, diff- entiation, or activation of cells involved in immunity and inflammation, and belong to a broader family termed cytokines. Collectively these proteins are the key orchestrators of host defense and the response to tissue injury. There are currently 23 different interleukins (numbered from IL-1 to IL-23), although the full extent of the interleukin family will only become clear upon analysis of the human genome sequence. Most important, interleukins are central to the pathogenesis of a wide range of diseases that involve an immune com- nent, including such conditions as rheumatoid arthritis, multiple sclerosis, ulcerative colitis, psoriasis, and asthma. Interleukins have also been imp- cated in other conditions, including cancer, migraine, myocardial infarction, and depression. In essence, when cells are activated by interleukins, a program of gene expression is initiated in the target cell that alters the cell’s phenotype, leading to enhanced immune reactivity, inflammation, and/or proliferation. Interleukins are therefore at the core of the cellular basis for many diseases. They are the subject of intense inve | | 出版日期 | Book 2001 | | 版次 | 1 | | doi | https://doi.org/10.1385/1592591469 | | isbn_softcover | 978-1-61737-162-2 | | isbn_ebook | 978-1-59259-146-6Series ISSN 1543-1894 Series E-ISSN 1940-6037 | | issn_series | 1543-1894 | | copyright | Humana Press 2001 |
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发表于 2025-3-21 18:04:03
