| 书目名称 | Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology | | 编辑 | Witold Lasek,Radoslaw Zagozdzon | | 视频video | | | 概述 | Explores the biology of interleukin 12 and its potential in cancer therapy.Discusses antitumor effects identified in preclinical studies and clinical trials in cancer immunotherapy.Is particularly rel | | 丛书名称 | SpringerBriefs in Immunology | | 图书封面 |  | | 描述 | .This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).. | | 出版日期 | Book 2016 | | 关键词 | Interleukin 12; Antitumor Effects; Cancer; Immunotherapy; Clinical Trials | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-46906-5 | | isbn_softcover | 978-3-319-46905-8 | | isbn_ebook | 978-3-319-46906-5Series ISSN 2194-2773 Series E-ISSN 2194-2781 | | issn_series | 2194-2773 | | copyright | The Author(s) 2016 |
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发表于 2025-3-21 17:44:22
